摘要
目的分析原发性系膜增生性肾小球肾炎(MsPGN)患者肾脏病理变化与临床特征之间的关系。方法108例原发性系膜增生性肾炎患者肾活检资料分别按Haas分型标准和Katafuchi半定量积分法判定肾脏病理学变化,并依系膜增生程度与肾小球毛细血管的关系分级,研究临床各指标与不同分型、分级之间的联系。结果108 例患者临床分型无症状血尿和(或)蛋白尿42例,血清肌酐值显著低于其它组(P<0.05)。Haas分型Ⅳ(30例)、Ⅴ型(8例)与Ⅰ(27例)、Ⅱ(17例)、Ⅲ(26例)型肾脏各项病理积分之间差别显著(P<0.05),而Ⅳ、Ⅴ型之间无显著差别。系膜增生程度与Haas分型之间呈正相关(r=0.662)。结论肾小球和小管间质病变均是影响MsPGN进展的重要因素。Haas分型和Katafuchi半定量积分法可以更加细致地判定系膜增生性肾炎病变程度。
Objective To analyze the clinical and pathological characteristics in 108 patients with primary mesangial proliferative glomerulonephritis（MsPGN）, then estimate their relationship. Methods All of 108 eases were diagnosed by renal biopsy. The degree of renal lesion was determined according to Haas criterion and Katafuehi semi-quantitative criterion respectively. Mesangial proliferative degree was graded according to the extent of glomerular capillary oppressed. Different clinical manifestations including asymptomatie hematuria or proteinuria, nephropathy syndrome, chronic nephritic syndrome, and pathological change were compared in variety levels and type. Results Forty-two eases who was diagnosed asymptomatie hematuria or proteinuria, their mean serum ereatinine concentration was lower than other groups（ P 〈 0. 05）. Renal pathological change score of both Haas IV（30 eases） and V（8 eases） groups were significantly different compared with Haas Ⅰ （27 ease）, Ⅱ （17 eases） and Ⅲ （26 eases）（ P 〈 0.05）. But there was no significant difference between Haas Ⅳ and Ⅴ groups. Mesangial proliferative degree was correlate with Haas classification （ r = 0. 662）. Conclusion Pathological changes of glomeruli and renal tubules are thought being important factors to evaluate the development of MsPGN equally. Haas classification and Katafuehi semi-quantitative scoring system can provide more particular data for diagnosis about the degree of MsPGN.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2005年第4期355-357,共3页
Journal of Harbin Medical University
关键词
系膜增生性肾小球肾炎
临床特点
病理改变
mesangial proliferative glomemlonephritis
clinical feature
pathological change
