摘要
针对苯丙氨酸解氨酶的新型酶生物传感器非线性特性,依据最小二乘法理论,采用最优化技术,建立了标定最佳拟合直线的数学模型,编写了数据拟合程序,实际运行结果表明,该方法克服了生物传感器校正传统方法拟合准确度低的缺点.
A novel phenylalanine ammonia-lyase biosensor has been developed for the detection of the genetic disorder, Phenylketonuria in clinic. To solve the non-linear problem of a biosensor, the least square method and the optimum technique have been applied to build a mathematical model to evaluate the optimum fitting straight. The related computer-calculating program is also described. Finally, the experimental results have shown that the new method described can solve the low accuracy problem persist in other conventional fitting methods.
出处
《哈尔滨工业大学学报》
EI
CAS
CSCD
北大核心
2005年第8期1085-1086,1112,共3页
Journal of Harbin Institute of Technology
基金
哈尔滨市科技攻关项目(9914211150)
关键词
生物传感器
苯丙氨酸解氨酶
线性化
最佳拟合直线
biosensor
phenylalanine ammonia-lyase
linearization
optimum fitting straight
