摘要
目的观察靶控输注(TCI)丙泊酚镇静对硬膜外麻醉患者血液动力学的影响,并确定血压降低50%的靶控浓度.方法28例择期行硬膜外麻醉手术的患者,ASA Ⅰ～Ⅱ级,年龄17～67岁,术中采用丙泊酚TCI镇静,靶控浓度从0.4μg/ml开始,以0.4μg/ml梯度逐渐上升,直至患者入睡并维持该浓度直至手术结束.麻醉中观察并记录SBP、DBP、MAP、HR和SpO2的变化.结果MAP和HR随靶控浓度的升高而降低,降低的平均幅度分别为23%和11%.MAP降低50%的靶控浓度为6.31μg/ml.结论硬膜外麻醉下丙泊酚TCI镇静时,达意识消失状态时的靶控浓度远低于EC50,镇静深度易于调控,血液动力学较稳定.
Objective To observe the effect of target controlled intravenous infusion of propofol on the hemodynamics during epidural anesthesia, and determine the EC50 of target-controlled concentration. Methods Twenty-eight patients, ASA grade Ⅰ -Ⅱ , received TCI propofol with pharmacokinetic parameter set reported by Marsh beginning with 0.4 μg/ml, increment of 0.4 μg/ml until the patients lose consciousness. Every target-controlled concentration maintained for 15 minutes at least.SBP,DBP,MAP, HR,SpO2 were recorded in all patients at the end of given target-controlled concentration. Results MAP and HR decreased gradually along with increasing of target-controlled concentration. The mean decreasing orange of MAP and HR were 23% and 11% respectively. The EC50 of target-controlled concentration of propofol for MAP was 6.31μg/ml. Conclusion Target-controlled concentration of propofol for sedation is far lower than EC50 during epidural anesthesia. It can maintain stable blood pressure and adjustment of depth of sedation accurately.
出处
《临床麻醉学杂志》
CAS
CSCD
2005年第8期514-515,共2页
Journal of Clinical Anesthesiology
