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乳腺癌组织相关基因位点杂合性缺失研究进展

Advances in Research on loss of Heterozygosity of Related Gene in Breast cancer
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摘要 乳腺癌是多基因变异引起的疾病,包括原癌基因的激活和抑癌基因的失活。而抑癌基因的失活是由于一条等位基因发生杂合性缺失(loss of heterozygosity,LOH),而另外一条等位基因紧接着发生突变。本文就乳腺癌组织相关基因杂合性缺失试做综述。1 P53P53定位于17 p13,长16～20 kb,
作者 乔峰 李曦洲 施俊义
机构地区 第二军医大学长海医院普四科
出处 《湖南中医药大学学报》 CAS 2011年第10期76-77,80,共3页 Journal of Hunan University of Chinese Medicine
关键词 乳腺癌 抑癌基因 杂合性缺失 breast cancer cancer suppressor genes loss of heterozygosity
分类号 R737 [医药卫生—肿瘤]
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参考文献20

  • 1Mads Thomassen,Qihua Tan,Torben A. Kruse.Gene expression meta-analysis identifies chromosomal regions and candidate genes involved in breast cancer metastasis[J]. Breast Cancer Research and Treatment . 2009 (2) 被引量：1
  • 2Naoki Tsuji,Kaori Furuse,Koichi Asanuma,Momoko Furuya,Kei Kondoh,Chinatsu Kamagata,Masateru Sasaki,Daisuke Kobayashi,Atsuhito Yagihashi,Hiroshi Takahashi,Naoki Watanabe.Mutations of the p53 Gene and Loss of Heterozygosity at Chromosome 17p13.1 are Associated with Increased Survivin Expression in Breast Cancer[J]. Breast Cancer Research and Treatment . 2004 (1) 被引量：1
  • 3Daniel F. Hayes,Claudine Isaacs,Vered Stearns.Prognostic Factors in Breast Cancer: Current and New Predictors of Metastasis[J]. Journal of Mammary Gland Biology and Neoplasia . 2001 (4) 被引量：1
  • 4Jose M. Garcia,Jose M. Silva,Gemma Dominguez,Rocio Gonzalez,Antonia Navarro,Luis Carretero,Mariano Provencio,Pilar Espa?a,Felix Bonilla.Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype[J]. Breast Cancer Research and Treatment . 1999 (3) 被引量：1
  • 5Jose M. Silva,Rocio Gonzalez,Mariano Provencio,Gema Dominguez,Jose M. Garcia,Isabel Gallego,Jose Palacios,Pilar Espa?a,Felix Bonilla.Loss of heterozygosity in BRCA1 and BRCA2 markers and high‐grade malignancy in breast cancer[J]. Breast Cancer Research and Treatment . 1999 (1) 被引量：1
  • 6Toshinari Yamashita,Hirotaka Iwase,Hiroko Yamashita,Hiroji Iwata,Kazuko Ito,Tatsuya Toyama,Yasuo Hara,Shunzo Kobayashi.Low frequency loss of heterozygosity in theBRCA1 region in Japanese sporadic breast cancer[J]. Breast Cancer . 1996 (3) 被引量：1
  • 7R ouba A,Kaisi N,Al-Chaty E,et al.Patterns of allelic loss at theBRCA1 locus in Arabic women with breast cancer. International Journal of Molecular Medicine . 2000 被引量：1
  • 8R hiem K,Todt U,Wappenschmidt B,et al.Sporadic breastcarcinomas with somatic BRCA1 gene deletions share genotype/phenotype features with familial breast carcinomas. Anticancer Research . 2010 被引量：1
  • 9S ilva Soares EW,de Lima Santos SC,Bueno AG,et al.Concomitantloss of heterozygosity at the BRCA1 and FHIT genes as aprognostic factor in sporadic breast cancer. Cancer Genetics and Cytogenetics . 2010 被引量：1
  • 10Brian JM,Daolong W,Ralf K,et al.Pooled analysis of loss ofheterozygosity in breast cancer:a genome scan provides comparativeevidence for multiple tumor suppressors and identifies novelcandidate regions. The American Journal of Human Genetics . 2003 被引量：1
湖南中医药大学学报
2011年 第10期

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