摘要
目的研究黄连素对家兔心肌缺血再灌注损伤的保护作用及其相关机制。方法采用在体兔心肌缺血再灌注损伤模型,将35只新西兰大白兔随机分为5组假手术组;模型组;黄连素小、中、大三个剂量组。监测各组如下指标:用试剂盒检测各组血清MDA、CPK的含量和SOD的活性;试剂盒检测各组心肌组织NO含量和NOS活性。结果黄连素可降低缺血再灌注损伤后血清MDA和CPK含量,提高SOD的活性;黄连素可提高心肌组织NO含量和NOS活性。结论黄连素预处理对家兔心肌缺血再灌注损伤具有保护作用。
Objective To investigate the antioxidant protective effect of berberine on myocardial ischemia/reperfusion injury in rabbits.Methods All rabbits were randomly divided into five groups: sham group;model group;three berberine treatment groups.These indexes are detected: The activity of SOD and CPK and the content of MDA in serum were detected using kits;The level of NO and the activity of NOS in myocardial tissues were detected using kits.Results The content of MDA in serum were reduced by berberine.The activity of SOD and CPK in serum were increased by berberine.The levels of NO and the activity of NOS were in myocardial tissues increased by berberine.Conclusion Berberine can protect cardiomyocyte from ischemia / reperfusion injury.
出处
《湖南中医药大学学报》
CAS
2011年第10期7-8,11,共3页
Journal of Hunan University of Chinese Medicine
基金
河北省卫生厅医学重点课题(20090390)
河北省中医局课题(2009035)
关键词
黄连素
心肌缺血再灌注损伤
兔
Berberine
Myocardial ischemia/Reperfusion injury
Rabbit
