摘要
目的观察克拉霉素、阿莫西林、奥美拉唑三联短程疗法对幽门螺杆菌(Hp)感染的根除率,探讨初治失败后治疗方案的选择。方法经胃镜检查、组织活检确诊为Hp感染患儿86例,男50例,女36例。分为克拉霉素组62例,用克拉霉素、阿莫西林、奥美拉唑三联1周疗法;甲硝唑组24例,用甲硝唑、阿莫西林、奥美拉唑三联2周疗法。停药后4周,检测Hp根除率。对2组初治失败者进行复治,克拉霉素组增加克拉霉素剂量和延长奥美拉唑疗程;甲硝唑组采用克拉霉素三联1周疗法。复治再失败者采用铋剂四联疗法。结果克拉霉素组Hp根除率91.9%(57/62)较甲硝唑组75%(18/24)高,有显著性差异(χ2=4.448P<0.05)。本组共11例根除失败,采用3种复治方法后,根除率分别为80%(4/5)、66.7%(4/6)、100.0%(3/3)。结论克拉霉素三联1周短程疗法是根除儿童Hp感染的理想治疗方案。适当增加克拉霉素剂量和延长奥美拉唑疗程可提高根除率。采用铋剂四联法对克拉霉素耐药者有效。
Objective To evaluate the eradication rate of a triple therapy consisted of clarithromycin(CLA),amoxicillin(AMO)and omeperazole to (Helicobacter Pylori) Hp infection,and explore the alternative therapeutic programs and their effects after first therapeutic failure. Methods 86 children were diagnosed to Hp infection by biopsy in stomach mucous membrane .50 cases were male and 36 cases were female. All cases were divided into two groups:62 cases were given the triple therapy for one week(CLA group);24 cases w...
出处
《中国中西医结合儿科学》
2006年第4期223-225,共3页
Chinese Pediatrics of Integrated Traditional and Western Medicine
关键词
儿童
幽门螺杆菌感染
克拉霉素
甲硝唑
铋剂
children helicobacter pylori infection clarthromycin metronidazole colloidal bismuth subcitrate
