摘要
目的探讨定期联合检测血清肿瘤标志物在非小细胞肺癌(NSCLC)预后中的意义。方法采用放射免疫法检测65例NSCLC患者手术前后和35例健康对照组的血清癌胚抗原(CEA)、细胞角蛋白19(CYFRA21-1)和肿瘤坏死因子(TNF)的含量。结果NSCLC组患者血清CEA、CYFRA21-1和TNF的含量均明显高于健康对照组(p<0.01),手术治疗后未复发转移组低于术前(p<0.01),复发转移组明显高于未复发转移组(p<0.01)。结论测定NSCLC患者血清中CEA、CYFRA21-1和TNF水平对患者的治疗和预后均有一定的临床价值。
Objective To study the clinical signification of the serum levels of carbohydrate antigen 125(CEA),cytokeratin 19-fragments(CYFRA21-1) and tumor necrosis factor(TNF) in patients with Non-Small Cell Lung Cancer(NSCLC).Methods Serum CEA,CYFRA21-1 and TNF levels were determined by with RIA in 65 NSCLC both before and after operation as well as in 35 controls.Results Operation,serum CEA,CYFRA21-1 and TNF levels in the NSCLC were significantly higher than those in the controls(p<0.01).The levels of CEA,CYFRA21-1 and TNF lower than that before surgery(p<0.01).Recrudesece group are higher than non-recrudesce group(p<0.01).Conclusion The serum levels of CEA,CYFRA21-1 and TNF are closely related to the tumor burden and may reflect the presence of recurrence.
出处
《医学检验与临床》
2006年第5期41-42,49,共3页
Medical Laboratory Science and Clinics
