摘要
目的 探讨α及β-受体阻滞剂卡维地洛对高血压病患者血压和心率变异性(HRV)的影响.方法 36例轻、中度高血压病患者服卡维地洛(25～50 mg/d,8周)前后测定血压和行24 h动态心电图检查分析心率功率谱时域和频域指标.结果 卡维地洛使高血压病患者血压明显下降,HRV时域指标每连续5分钟时段平均值轻度降低,正常RR间期的标准差、每连续5分钟时段标准差、相邻RR间期之差的均方根值和频域指标高频轻度增加,频域指标总频谱、低频和低频与高频比值明显降低.结论 卡维地洛对高血压病患者降压的同时,对心率变异性产生有益的作用.
Objective To evaluate the effects of α and β adrenoceptor antagonists(carvedilol) on blood pressure and heart rate variability(HRV) in patients with essential hypertension. Methods Thirty-six patients with mild to moderate essential hypertension, who administered carvedilol(25-50 mg/d) for 8 weeks, were checked blood pressure and 24 hours ambulatory ECG for detecting of HRV. Results After and before treatment, blood pressure were markedly reduced as well as standard deviation of normal RR intervals(SDNN). While the standard deviation of 5 minute mean RR intervals(SDANN),the square root of the mean of squared difference between adjacent normal RR interval(RMSSD) and high frequency(HF) components of power spectrum density were significantly increased. Total frequency(TF),low frequency(LF) and high/low frequency ratio were markedly reduced. Conclusions Suggests carvedilol therapy can markedly reduce blood pressure and increase the heart rate variability of patients with essential hypertension.
出处
《中国实用医刊》
2010年第19期12-13,共3页
Chinese Journal of Practical Medicine
关键词
高血压病
心率变异性
卡维地洛
Essential hypertension
Heart rate variability
Carvedilol
