摘要
目的 通过研究高原人工富氧环境(简称富氧室)对急进高原人员睡眠的作用,探讨富氧室的抗缺氧效果及其与高原习服的关系. 方法 利用分子筛制氧机在海拔3500 m高原建立富氧室.将18名世居平原人员随机分为富氧组、缺氧组和平原组,每组各6人.平原组不进入高原,富氧组和缺氧组人员乘飞机到达高原后,在未供氧情况下记录2组受试人员的心率和血氧饱和度(arterial oxygen saturation,SaO2).当晚22:00两组人员分别进入富氧室和普通房间,休息至次日上午9:00通过睡眠呼吸记录分析系统,对受试人员进行监测,在同一时间对平原组也进行监测.数据采集完毕后利用系统自带分析软件进行分析. 结果 ①富氧组供氧后SaO2为92.3%.±1.0%,高于供氧前的82.9%±4.2%和缺氧组的79.3%±5.9%(P<0.01),但低于平原组的97.3%±0.8%(P<0.05),且差异均有统计学意义.心率值在富氧组供氧前后及与缺氧组间差异无统计学意义,但均高于平原组,且差异有统计学意义(P<0.01).②睡眠结构富氧组与缺氧组差异无统计学意义,与平原组比较浅睡眠偏多,深睡眠偏少,且差异有统计学意义(P<0.01).低通气次数和呼吸紊乱指数平原组低于缺氧组和富氧组(P<0.01);富氧组呼吸紊乱指数低于缺氧组,两组分别为28.1±11.9和53.2±23.4,且差异有统计学意义(P<0.05).③睡眠期间,富氧组和缺氧组的归一化低频功率和低频与高频的比值分别为89.3±2.9、9.4±2.8和90.2±1.8、9.9±1.9,组间差异无统计学意义,但均高于平原组的85.8±2.9和6.4±1.4,且差异有统计学意义(P<0.05);平原组的归一化高频功率则高于富氧组和缺氧组,且差异有统计学意义(P<0.05). 结论 高原富氧室可以有效改善急进高原人员睡眠情况,但对睡眠期间心率变异性未见显著影响,且与高原习服的关系尚待深入研究.
Objective To study the effects of the artificial oxygen-enriched environment (is called 'oxygen-enriched room' in short) on sleep efficiency of the people who participate in the mission on plateau with hurry-up entry,and to investigate the anti-hypoxia effect of oxygen-enriched room to plateau acclimatization. Methods Eighteen subjects were randomly and averagety allocated into plain group,oxygen-enriched group and hypoxia group.Only the later two groups were dispatched to plateau by air.Molecular sieve oxygenerator was used to supply the room with oxygen on 3500 m plateau.The oxygen-enriched group and hypoxia group got into the oxygen-enriched rooms and normal rooms respectively at 22 o' clock and took rest till to 9 o' clock next morning.The changes of heart rate (HR) and the saturation of blood oxygen (SaO2) of three groups were recorded and compared between the states of with and without oxygen enrichment.The subjects were monitored by sleep respiration recording and analysis system. Results ①The SaO2 of the oxygen-enriched group was 92.3%±1.0%,and it was significant higher than the state before oxygen enrichment (82.9%±4.2%) and than that of hypoxia group (79.3%±5.9%,P<0.01),but lower than that of plain group (97.3%±0.8%,P<0.05).②There were less deep sleep and more slight sleep in hypoxia group and oxygen-enriched group than in plain group.The hypopnea and apnea hypopnea index (AHI) of plain group was significant lower than that of hypoxia group and oxygen-enriched group (P<0.05).The AHI of the oxygen-enriched group was 28.1±11.9,and it was significant lower than that of hypoxia group (53.2±23.4)(P<0.05).③The normalized low-frequency (Ln) and the ratio of low-frequency to high-frequency (LF/HF) measured in sleep was respectively 89.3±2.9 and 6.4±1.4 in oxygen-enriched group comparing to 90.2±1.8 and 9.9±1.9 in hypoxia group but without statistical difference.The corresponding Ln and LF/HF of plain group was 85.8±2.9 and 6.4±1.4 respectively,significantly higher than those of other two group
出处
《中华航空航天医学杂志》
CSCD
2010年第1期51-55,共5页
Chinese Journal of Aerospace Medicine
关键词
高海拔
缺氧
睡眠
心率
富氧室
Altitude
Anoxia
Sleep
Heart rate
Oxygen-enriched room
