摘要
目的 探讨联合应用血氧水平依赖功能性磁共振成像(BOLD-fMRI)和弥散张量成像(DTI)技术评价高压氧治疗视觉障碍的疗效.方法 选取视通路异常患者16例为研究组,采用高压氧治疗,并于高压氧治疗前、后行视觉BOLD-fMRI和全脑DTI检查,选取性别、年龄与研究组大致匹配的正常视力健康志愿者12例为对照组,行视觉BOLD-fMRI和全脑DTI检查,并与研究组的视觉BOLD-fMRI和DTI结果进行比较.结果 研究组治疗前的被试视觉BOLD-fMRI视皮质激活体素、视放射各向异性值(FA值)与对照组比较差异有统计学意义(P<0.01);研究组高压氧治疗后视觉BOLD-fMRI视皮质激活体素、视放射各向异性值(FA值)与对照组结果比较差异无统计学意义(P>0.05),与治疗前比较差异有统计学意义(P<0.05).结论 血氧水平依赖功能磁共振成像联合弥散张量成像能从解削功能学角度量化研究视通路病变视觉异常的高压氧治疗效果,是视觉脑功能康复疗效评价的可靠手段,有重大临床应用价值.
Objective To evaluate the rehabilitating effect of hyperbaric oxygen on visual pathway lesions with blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI) and diffusion tensor imaging (DTI). Methods Sixteen patients with visual pathway lesions (the study group) and twelve healthy volunteers (the control group) were assessed using BOLD-fMRI and DTI. After hyperbaric oxygen therapy, the patients in the study group were again assessed using BOLD-fMRI and DTI. The activated regions of the BOLD-fMRI scan and the fractional anisotropy (FA) value determined from the DTI were calculated. Results Before hyperbaric oxygen treatment, there were significant differences between control and study groups in their BOLD-fMRI activated regions and the FA values of their radiation optics (P≤0.01). After hyperbaric oxygen treatment, there were no significant differences. Conclusion Combining BOLD-fMRI with DT1 could be used to evaluate the rehabilitation effect of hy-perbaric oxygen treatment in patients with visual pathway lesions.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2009年第1期36-42,共7页
Chinese Journal of Physical Medicine and Rehabilitation
基金
福建省自然科学基金（2006J0192）
南京军区计划课题(06249)
关键词
视觉
功能性磁共振成像
弥散张量成像
高压氧
Visual rehabilitation
Functional magnetic resonance imaging
Diffusion tensor imaging
Hyperbaric oxygen therapy
