摘要
采用限制性酶切片段长度多态性分析法，检测在胃癌高发区庄河检出的１９例胃癌高系家族成员胃蛋白酶原Ｃ基因多态性，发现三种常见片段及一种稀有片段。对其中４例携带稀有片段的受检者进行了胃镜追踪观察，２．５年后发现１例早期胃癌。本文对此作了初步探讨。
he restriction fragment length polymorphism( RFLP ) of
pepsinogen C genes in 19 members fromhigh risk family of stomach
cancer was analysed.hree common fragments and 1 rare fragment
werefound. Four cases bringing rare fragment were further followed
up by endoscope and one early gasriccancer was found after 2. 5
years.
出处
《中国医科大学学报》
CAS
CSCD
1995年第4期356-357,共2页
Journal of China Medical University
基金
辽宁省科委重点课题
关键词
胃肿瘤
胃蛋白酶原C
基因多态性
高系家族
pepsinogen C gene restriction fragment length
polymorphism
high risk family
stomach cancer
