摘要
本文着重研究盐酸吗啡ＦＲ１：１，４ｈ猴自身给药实验模型的建立。结果显示，此模型潜伏期较长，但在注射次数稳定平台形成以后，踏板及注射次数客观地显示出盐酸吗啡作为强化剂能够维持猴的觅药行为，各平台注射次数之间均有显著性差异（Ｐ＜０．０１），但每日摄入量变化不明显。长达６０ｄ的实验，在自然戒断后，戒断症状不明显。实验表明，此精神依赖性模型的建立是成功的，且非常稳定可靠。本文还详细介绍了猴自身给药实验的手术、实验过程及维护等实验方法，为药理学工作者提供了自身给药实验的方法学参考依据。
An intravenous self-administration(iv SA) model in rhesus monkeys hasbeen set up. in our lab. Under fixed ratio 1: 1 and 4 hours to access to morphine at trainingdose 0. 25 mg kg-1, the previous naive monkeys could learn to press lever and maintain ivSA spontaneously. After the total daily dose reached a platform. the injection dose wasreduced. As a result the times of pressing lever increased. While increasing the dose lowerresponse occurred. In this experiment the withdrawal syndrome was not apparently seenafter the morphine was substituted by normal saline in morphine SA monkeys. The establishment of iv SA was very successful, which would be a good method for evaluating theabuse liability of drugs.
关键词
自身给药
精神依赖性
药物依赖性
动物模型
self -- administration
psychic dependence
morphine
fixed ratio
drugseeking behavior
total daily dose
