摘要
观察大黄素（Ｅｍｄ）和番泻甙Ａ（ＳｅｎＡ）对ＮＥ和高Ｋ＋诱导的兔主动脉条（ＲＡ）收缩作用的影响。结果表明，小剂量大黄素（１８．５μｍｏｌ·Ｌ－１）和番泻甙Ａ均可使ＮＥ和高Ｋ＋诱导的ＲＡ收缩的量效曲线左移，其作用原理可能与钙激动作用有关。大剂量大黄素（９２．５μｍｏｌ·Ｌ－１）抑制ＲＡ收缩作用，量效曲线右移，其作用可能与大黄素络合游离Ｃａ２＋作用有关。
Experiments were performed in isolated rabbit aorta strips. Both KCl(10～40 mmol·L-1) and NE(0.27～7.29μmol·L-1) elicited concentration-dependent contraction of rabbit aorta strips.Emodli(Emd,18.5 μmol·L-1) increased the amplitude of contractions both induced by KCl and NE, and the dose-effect curves of the contraction shifted to the left. The same effect was observed in the pretreated with Sennoside A(Sen A,116 and 348 μmol·L-1). When the preparations were exposed to Emd 92.5 μmol·L-1 under the presence of the both high K+ and NE, the amplitude of the contraction was attenuated and the dose-effect curves of the contraction shifted to the right, The results suggest that Emd has a Ca2+ agonistic action in lower concentration and a chelating calcium action in higher concentration. (The project is supported by National Nature Science Foundation of China 39170910)
出处
《中国药理学通报》
CAS
CSCD
北大核心
1995年第5期371-374,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金
关键词
大黄素
番泻甙
兔主动脉条
钙通道
Emodin
Sennoside A
rabbit aorta strip
calcium channel
