摘要
在大鼠ｓｃ异丙肾上腺素（０．８３μｍｏｌ·ｋｇ－１·ｄ－１）造成的心肌损伤模型上观察腐胺的作甲。结果表明，腐胺（１．８５×１０－１，６．１７×１０－１ｍｏｌ·ｋｇ－１·ｄ－１．ｉｖ）可明显减轻由异丙肾上腺素引起的心肌损伤，缓解心功能衰竭，抑制乳酸脱氢酶的漏出，减少异丙肾上腺素引起的心肌丙二醛和心肌组织钙的聚集。提示腐胺对于缺血性心脏疾病可能具有一定的防治作用。
Cardio-protective action of putrescine was observed on the myocardial injury model produced by subcutaneous injection of isoproterenol(83μmol· kg-1·d-1) into rats.Pretreatment with putrescine(1. 85× 10-4,6.17×10-4mol·kg-1· d-1, iv)significantly ameliorated isoproterenol-induced myocardial lesion : inhibited the increase of myocardial calcium accumulation and lipid peroxidation ptoducts( malondialdehde,MDA) ;lowered me level of plasma lactate dehydrogenase( LDH) and MDA. These results suggest that putrescine may have potential significance for clinical therapy of ischemic heart disease.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1995年第1期77-79,共3页
Chinese Pharmacological Bulletin
关键词
腐胺
异丙肾上腺素
心肌损伤
心肌保护
isoproterenol
putrescine
myocardial necrosis
myocardial protection
