摘要
本文观察了５４例急性心肌梗死（ＡＭＩ）患者发病３天内红细胞变形能力（ＥＤ）和红细胞三磷酸腺苷酶（ＡＴＰａｓｅ）活性及红细胞内离子浓度的变化，并分析其相互关系。结果显示，ＡＭＩ患者红细胞滤过指数（ＩＦ）校对照组明显增高（Ｐ＜０．００１）。红细胞Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－Ｍｇ２＋－ＡＴＰａｓｅ活性和红细胞Ｋ＋、Ｍｇ２＋浓度明显降低，而红细胞Ｎａ＋、Ｃａ２＋浓度明显增高，与对照组相比差异有显著性意义（Ｐ＜０．００１）。ＡＭＩ患者红细胞ＩＦ与红细胞Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－Ｍｇ２＋－ＡＴＰａｓｅ活性、红细胞Ｋ＋、Ｍｇ２＋浓度呈负相关（Ｐ＜０．００１），与红细胞Ｎａ＋、Ｃａ２＋浓度呈正相关（Ｐ＜０．００１）。这提示ＡＭＩ患者ＥＤ降低与红细胞ＡＴＰａｓｅ活性和Ｋ＋、Ｍｇ２＋浓度降低及Ｃａ２＋、Ｎａ＋浓度增高有关。
Erythrocyte deformability(ED) and erythrocyte ATPase activitiy as well as erythrocyte ionic concentration were observed in patients with acute myocardial infarction(AMI). The erythrocyte filtration index(IP) was significantly higher in AMI patients than in controls(p<0. 001), the activities of Na￣+-K￣+-AT-Pase, Ca￣(2+)-Mg￣(2+)-ATPase and erythrocyte K￣+ , Mg￣(2+)concentrations were all significantly lower in the patients, but erythrocyte Ca￣(2+) , Na￣+ concentrations were significantly higher than in controls (p<0. 001). In AMI patients, the erythrocyte iF negatively correlated with Na￣+-K￣+-ATPase , Ca￣(2+) -Mg￣(2+) -ATPase activities and erythrocyte K￣+, Mg￣(2+) concentrations,and positively correlated with Na￣+ , Ca￣(2+) concentrations. These results indicated that decrease of ED in AMI patients was related to the decrease of erythrocyte ATPase activities and change of erythrocyte ionic concentrations.
出处
《中国循环杂志》
CSCD
1995年第5期268-270,共3页
Chinese Circulation Journal
关键词
心肌梗死
红细胞
三磷酸腺苷酸
Acute myocardial infarction
Erythrocyte
Rheology
ATPase
Ions
