摘要
本工作首次利用声源发作大鼠动物模型，以其行为表现分Ⅴ级，观察氯硝基安定短期处理组、长期处理组和对照组大鼠对铃声刺激后的行为表现，并对脑组织谷氨酸脱羧酶进行测定。结果显示：铃声刺激使对照大鼠全部惊厥；氯硝基安定短期处理后对铃声刺激无反应；而在氯硝基安定长期处理后，铃声刺激使大鼠的表现与对照组相似；而上述三组大鼠的脑组织谷氨酸脱羧的活性各组之间无显著性差异。提示：氯硝基安定能明显拮抗大鼠的声源性发作；但长期应用使抗痫作用明显下降，表现为耐受；这种耐受与谷氨酸脱羧酶无关。
To investigate the behavior and the ability of glutamic acid decarboxylase(GAD).the audiogenic seizure rats in control.short time and long time-clonazepam pretreated groups were used. The results showed that(1) The bell-stimulation made control rats convulsion;(2) short time- CZP pretreated rats did no response to bell;(3) Long time-CZP pretreated rats resembled with the control rats.The activities of GAD were not significant differences among control, short time-and long time-CZP pretreated gtoups The results suggested (1) CZP inhibit the convulsion of audiogenic seizure significantly, but long time CZP used ,the antiepileptic effects were diminished significantly,e.g.tolerance;the mechanisms of tolerance were not associated with GAD.
出处
《中国行为医学科学》
CSCD
1995年第2期72-73,共2页
Chinese Journal of Behavioral Medical Science
关键词
氯硝基安定
声源性发作大鼠
抗惊耐受
癫痫
Clonazepam
audiogenic seizure rat
anticonvulsant tolerance
glutamic zcid decarboxylase.
