摘要
为探讨烧伤后持续高代谢状态在多器官衰竭（ＭＯＦ）发生发展中的作用，建立了烧伤后高代谢和ＭＯＦ的动物模型。用９５℃水烫山羊造成２０％～２５％体表面积的Ⅲ度烧伤，观察氧动力学及反映器官功能的一系列指标。发现１６只山羊中有１１只发生了高代谢伴有高动力循环。这些动物存活５～１０天，其中１０只发生了ＭＯＦ，发生率为９０．９％。５只未发生高代谢的山羊在伤后４８ｈ内死亡，其中１只发生ＭＯＦ。高代谢一般在烧伤后第１～２天出现，第３天达高峰，ＭＯＦ多在伤后第２～５天发生。提示：持续高代谢状态在ＭＯＦ的发生发展中可能起着某种促进作用。因此，创伤后高代谢反应时必须把代谢率控制在适度范围，防止多器官衰竭的发生。
In order to
evaluate the effect of the postburn per-sistent hypermetabolism
on
the emergence and evolutionof multiple organ failure(MOF),animal experimentalmodel of
hypermetabolism and MOF was established.16goats were burned(3rd degree,20%-25%of the
totalbody surface area) by using hot water. Parameters re-flecting oxygen dynamics and organ
function were stud-ied before and after burns. 11 out of the 16 goats devel-oped
hypermetabolism associated with hyperdynamic cir-culation. MOF occurred in 10 of the 11
goats with an in-cidence rate of 90.9%。 Among the five non-hyperme-tabolic animals, only one
goat developed MOF with anincidence of 20.0%. Hypermetabolism mostly occurredon the lst
day after burn and became obvious on the 2ndday.MOF developed 2-5 days after burn in most
ani-mals. It is suggested that persistent hypermetabolic statemay play an important role in the
emergence and evolu-tion of MOF.
出处
《中国危重病急救医学》
CAS
CSCD
1995年第6期349-351,共3页
Chinese Critical Care Medicine
基金
全军"八五"攻关课题
关键词
烧伤
高代谢
多器官衰竭
hypermetabolism
multiple organ failure
