摘要
５６例经内镜确诊的消化性溃疡和急性胃粘膜病变所致的上消化道出血患者，随机分成奥美拉唑组和法莫替丁组，分别接受奥美拉唑（４０ｍｇ／ｄ；ｉｖ）和法莫替丁（４０ｍｇ／ｄ；ｉｖ）治疗，疗程５ｄ。奥美拉唑组，３ｄ止血率为８４．６０％，５ｄ止血率为９２．３０％，其显效率明显高于法莫替丁组（４６．７０％），但总有效率与法莫替丁组（８３．３０％）比较无明显差异。研究结果表明：用奥美拉唑治疗上述原因所致的上消化道出血，安全、有效、止血迅速。
Fifty-six patients with upper gastrointestinal bleeding caused by peptic ulcer and acute gastric mucosal lesion were randomly allocated to intravenous therapy with omeprazole(Losec,Astra) 40 mg once daily or famotidine(pepcidine,MDS)20 mg twice daily for 5 days. Successful therapy was proven by endoscopy at the end of day 3 or day 5. Bleeding for more than 5 days was considered failure.The hemostatic rates of omeprazole and famotidine for 3 days were 84.6% and 46.7%,and for 5days were 92.3% and 83.3%,respectively,Omeprazole was more effective than famotidine in hemostatic rate for 3 days(P<0.01),but there was no significant difference between omeprazole and famotidine groups for 5 days(P>0.05).
出处
《中国临床药理学杂志》
CSCD
北大核心
1995年第4期206-209,共4页
The Chinese Journal of Clinical Pharmacology
关键词
奥美拉唑
法莫替丁
上消化道出血
消化性溃疡
omeprazole
famotidine
upper gastrointestinal bleeding
intravenous administration
