摘要
以乳酸环丙沙星（ＣＰＬＸ）注射液和氧氟沙星（ＯＦＬＸ）注射液随机分组治疗各种细菌性感染４０例及４２例，并以注射用头孢噻肟钠（ＣＴＸ）治疗４９例作对照。三组平均年龄、体重、疗程及病情程度相比无显著性差异，具可比性。病种分布以消化道感染最多，共８１例，占总数的６１．８％。三组１３１例病人细菌阳性率为９４．７％。一疗程ＣＰＬＸ组、ＯＦＬＸ组、ＣＴＸ组治愈率分别为８７．２％、８３．３％、７１．４％，有效率分别为８７．２％、９７．６％、８３；７％；细菌清除率分别为８９．２％、９７．４％、８９．８％。三组治愈率及细菌清除率比较无显著性差异，有效率比较Ｐ＜０．０５。体外抗菌活性检测示ＣＰＬＸ对伤寒沙门氏菌、痢疾志贺氏菌的ＭＩＣ卯均为０．１２μｇ／ｍｌ，ＯＦＬＸ则均为０．２５μｇ／ｍｌ。不良反应发生率三组分别为１５．０％、９．５％、１２．２％（ＰＬＸ组和ＯＦＬＸ组主要是静脉炎。本文结果表明乳酸环丙沙星注射液和氧氟沙星注射液是治疗多种细菌所致中、重度感染的安全有效的抗菌药物。
The clinical efficacy of intravenous ciprofloxacin lactate(CPLX)andintravenous ofloxaicn(OFLX ) was observed in a randomized groups of patients. 40 casesand 42 cases of bacterial infection were treated with CPLX and OFLX respectively. and 49cases were treated with cefotaxime(CTX) as the controlled group. In. all cases there were 81cases(61.8%) of gastrointestinal tract infection. The cure rates were 87.2%, 83.3%and71.4%, the bacterial eradication rates were 89.2%, 97.0%and 89.8%respectively inCPLX. OFLX and CTX groups(P>0. 05). The total effective rates were 87.2%, 97.6%and 83.7%respectively in the three groups(P<0. 05). The isolated pathogens were tested for susceptibility with MIC experiments. Resultsshowed the antibacterial activities in vitro of CPLX and OFLX for Gram-negative bacteriawere excellent.CPLX and OFLX are considerd to be good drugs of choice for treatment ofinfection caused by sensitive pathogens.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1995年第2期118-122,共5页
Chinese Journal of Antibiotics
