摘要
应用免疫增强剂“４２５”及其主要成分阿魏酸经腹腔分别注射感染日本血吸虫小鼠后１４～２９ｄ，两者均使小鼠肝组织内抗原水平显著地低于对照组（Ｐ均＜０．０５），前者还可使肝组织内特异性抗体（ＩｇＧ）水平显著地高于对照组（Ｐ＜０．０１）；注射α－干扰素对肝组织内抗原及抗体水平均无明显影响；但注射三种不同药物后小鼠肝组织内虫卵肉芽肿反应增长比均显著地小于对照组（Ｐ均＜０．０１）。结果进一步证实了以往的报道，通过体液免疫和细胞免疫不同途径的抑制或调节作用，可使虫卵肉芽肿病变减弱，并提示免疫增强剂“４２５”可能含有同时刺激宿主体液免疫和细胞免疫的成分，阿魏酸还可能有直接影响毛蚴分泌ＳＥＡ的作用。
days after Schistosoma japonicum-infected mice were injected intraperi-tonccaally with immunoenhancing reagent ,chinese agelica root extract“425”(Group Ⅲ)and ferulicacid(one of the “425”active components)(GroupⅠ) respectively,the antigen levels became signif-icantly lower in Group Ⅲ and in Group Ⅰ than those of the control group(P<0.05) ,and thespecific antibody (IgG) levels became significantly higher in Group Ⅲ than those of the controlgroup (P<0.01 ).14-29 days after Schistosoma japonicum-infected mice were injected in-traperitoneally with interferon-αGroup Ⅱ),the specific antibody(IgG)and antigen levels inGroup Ⅱ were not different from those of the control group.The ratios of granulomas vs.eggsmean diameters in the three experiment groups were all significantly lower than those of the con-trol group(P<0.01).The results further confirmed that both antibody and cell-mediated im-mune response can modulate Schistosoma japonicum egg granulomatous formation as it was re-ported previously. These data may also indicated that there are components that can simultane-ously induce antibody and cell-mediated immune response in immunoenhancing reagent, chineseagelica root extract“ 425”. Furthermore, the ferulic acid might exert a direct influence on theMiacidium secreting soluble egg antigen (SEA).
出处
《中国寄生虫病防治杂志》
CSCD
1995年第1期45-48,共4页
Chinese Journal of Parasitic Disease Control
基金
卫生部医学科学基金
关键词
日本血吸虫
虫卵肉芽肿
免疫增强剂
干扰素
Schistosama japonicum egg granuloma formation immunoenhancing reagent"425"ferulic acid interferon-2
