摘要
对汉中市心血管病防治区经过5年随访。血压偏高（HBP）和血压正常（NBP）及有高血压家族史（FH+）少年儿童（共310名，年龄10～15岁），进行口服盐水负荷和血浆胰岛素Ins）等测定。发现收缩压一直处于高百分位（P≥75）及FH+者．血Ins均明显高于NBP及FH-者。Ins≥P75者，红细胞Na－Li反转运速率增快，收缩血压增长幅度及盐水负荷后尿钠量均明显大于≤P50者。提示胰岛素抗性与盐敏感性相联系，在少儿已发挥作用，参与高血压的始动机制。
In this study of 310 school children, an oral saline load test was performed. Plasma insulin and the related parameters were measured. All the children in this study are from Hanzhong' south of Shan'xi, aged 10 ~ 15, grouped into higher vs normal blood pressure,with or without hypertension family history(FH). All the groups are matched for their sex and age,and followed up for 5 years. In the children with their systolic blood pressure on higher percentiles and with FH+, the plasma insulin was significantly higher than that in their respective control group. In children with the plasma insulin level equal to or greater than the 75th percentiles (≥P75 ). The RBC-Na/Li counter-transport rate was accentuated, the systolic blood pressure increment and 6 hour urinary soc1ium excretion after salt load were greater than those in the ≤P50 group. It is suggested that insulin resistance is associated withsalt-sensitivity, which may play a role in the development of hypertension in childhood.
基金
国家"八五"卫生科技攻关课题!85-915-01-04
关键词
高血压
盐敏感性
胰岛素
青少年
children
hypertension
salt-sensitivity: insulin
