摘要
本实验复制了慢性氟中毒大鼠病理模型、对血清碱性磷酸酶(ALP_(ase))活性和钙、磷水平进行了动态观察。结果表明,血清碱性磷酸酶活性在中毒14d内升高,然后下降,在30d时达到谷底,到90d时又恢复到原水平。而血清钙、磷水平在14d以后才开始下降,30d达到谷底,90d恢复到原水平。这一变化规律在饮水含氟(NaF)达0.1mg/mL时最明显。本文用“Mg^(2+)假说”解释了这一变化规律。同时对氟中毒的损伤机制做了初步探讨。
The animal model of chronic fluorosis in rat was replicated, and the changes of alkalin phos-phatase ALPase and calcium, phosphorus in serum of the tat was observed. The results showed that the activity of ALPase in serum was increased in 14 days of f luorosis, (P<0. 01), and then, it began to decrease. Untill 30 days it reached the lowest (P<0. 01) , but recoveried normal level again in 90 days. The levels of calcium and phosphorus in serum began decreased untill 14 days. They reached the lowest levels in 30 days, (P<0. 01). But they recovered-normal levels again in 90 days. These changes are markeder when the dose of fluoride poisoning reached 0. 1mg/ml water. To explain these changes the report advances a 'Mg++hypothesis', and discusses the mechanism of fluoride poisoning.
出处
《中国地方病防治》
北大核心
1995年第3期130-132,共3页
Chinese Journal of Control of Endemic Diseases
基金
卫生部地病局的骨病机制研究基金部分资助项目
