摘要
心脉灵以中医四逆汤为基础经剂型变化而得，具有回阳救逆之功效。以往的实验提示心脉灵有良好的抗内毒素休克作用。本实验用异硫氰酸荧光素右旋糖酐，分子量４０，０００（ＦＤ－４０Ｓ）观察发现：内毒素血症大鼠在给内毒素（ＥＴ）ｉ．ｖ后，１、３ｈ血浆荧光素下降率比对照组明显增加，支气管肺泡灌洗液（ＢＡＬ）中荧光素增长率相应地明显升高，同时发现血浆及肺组织脂质过氧化物也显著增高。事先给予心脉灵（ＸＭＬ），血浆荧光素下降曲线明显抬高，ＢＡＬ中荧光素上升曲线显著下移，血浆及肺组织脂质过氧化物也明显降低。提示内毒素血症大鼠肺血管通透性增加与脂质过氧化的增加有密切的关系，而心脉灵可能抑制肺脂质过氧化物的产生，从而改善了肺血管通透性。
In an attempt to define the effects of endotoxin on pulmonary micro-vascular permeability,we studied the movement of FIFC-dextran:MW 40000 (FD-40S)between plasma and bronchialalveolar lavage(BAL),compared with control group,FD-40S in plasma of endotoxin(ET)group markedly decreased at 1h、3h time pionts.By contrary,FD-40S in BAL increased significantly at same time pionts.Lipoperoxide(LPO)in plasma and lung tissue rose notably at 3h over the baseline value.Compa-red with ET group,XML+ET group had an increase of FD-40S in plasma and a fallof FD-40S in BAL;LPO in plasma and lung tissue decreased significantly at same timepionts.These data suggested the relationship between pulmonary microvascular permea-bility and LPO during endotoxemia state and indicated that XML should attenuate lunginjury by inhibiting LPO production.
出处
《中国病理生理杂志》
CSCD
北大核心
1995年第3期226-229,共4页
Chinese Journal of Pathophysiology
基金
高等学校博士学科点专项科研基金
关键词
内毒素血症
肺血管通透性
过氧化脂质类
心脉灵
Endotoxemia
Pulmonary microvascular permeability
Lipid peroxides
Medicine
Chinese traditional
