摘要
L-乳酸与三氟乙酸酐反应,生成L-α-三氟乙酰氧基乳酸,再与二氯亚砜作用,合成新的手性试剂-L-α-三氟乙酰氧基丙酰氯。它与DL-α-苯乙胺及三种DL-α-氨基酸反应,生成相应的非对映异构体酰胺,在以Carbowax为固定相的毛细管柱上进行气相色谱拆分。以相应的L-胺及L-氨基酸在相同条件下进行比较,发现D-异构体的保留时间较短。
A new chiral reagent L-α-trifluoroacetoxy propionyl chloride was easily synthe-sised by reactions of L-lactic with trifluoroacetic anhydride and thioryl chloride. Racemic amine and amino acids were resolved by derivatization to their corresponding diastereoisomeric amides with L-α-trifluoroacetoxy propionyl chloride on a capillary column with Carbowax 20 M as the stationary phase of gas chromatography. Under the same conditions, L-amine and L-amino acids were determined. The D-isomers of racemic amine and amino acids were found to have shorter rentention time.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
1995年第2期145-149,共5页
Chinese Journal of Organic Chemistry
基金
国家教委国内访问学者基金
关键词
苯乙胺
氨基酸
气相色谱
外消旋胺
TFAPC
L-α-trifluoroacetoxy propionyl chloride, α-phenyl ethylamine, amino acid, gas chromatography
