摘要
单剂量iv 60 mg/kg和po 200 mg/kg 羟乙桂胺后,用HPLC内标定量法进行血药浓度测定和药物动力学研究,血药浓度-时间曲线符合二室开放模型。po的生物利用度为21.36％;T_(1/2) β为3.15h。本法简便、快速。
With nipagin A as internal standard, the idrocilamideconcentration in plasma was determined. The pharmacokinetics of idrocilamidewas studied in rabbits after iv 60mg/kg and po 200mg/kg. The pharmacokineticparameters were calculated utilizing a 2-compartment open model.The eliminationhalf-life (T_(1/2β))was 3.15 h. The bioavailability after po was 21.36%
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1989年第10期467-469,共3页
Chinese Journal of Pharmaceuticals
