摘要
本文对18名需用雷公藤多甙(GTW)治疗的牛皮癣男性患者进行了药前,药后3、6个月及停药后3个月的精浆肉毒碱和果糖含量进行测定,来了解 GTW 对人附睾功能的影响。结果表明,服药后3及6个月精浆肉毒碱明显低于药前(P<0.05),但停药后3个月与药前相比无明显差异。结果提示,GTW 可能通过抑制附睾功能而阻碍精子的成熟,这可能是其抗生育的主要机制。
To evaluate the effect of multiglycosides of Tripterygium wilfordii(GTW)on epididymal function,we studiedthe seminal carnitine and fructose levels in 18 males taking the drug for the treatment of psoriasis.The results indicated that the seminal carnitine levels were significantly lowered 3 and 6 months after medica-tion.In the meantime,the ejaculated sperm dropped to the level of infertility.The seminal carnitine levels wererecovered 3 months after withdrawal of the drug.The seminal fructose levels did not change significantly.We conc-luded that interference in the epididymal function may be one of the important mechanisms of action of GTW.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1989年第1期29-30,共2页
Chinese Pharmaceutical Journal
关键词
雷公藤
附睾
情浆
内毒碱
Tripterygium wilfordii
epididymis
seminal plasma
carnitine
