摘要
本文首次在酸性介质中对卡铂与氯化亚锡的络合反应进行了详细的研究，确定了较好的反应条件，以３９２ｎｍ为测定波氏，测定白蛋白微球中卡铂的含量。线性范围１０～５０μｇ／ｍｌ，方法回收率大于９５．Ｏ％，ＲＳＤ＜２％。本法简便、灵敏、无干扰，适合原料药与制剂的分析。
The chelating reaction of Garboplatin with SnCl2 in acid medium is studied in detail at first in this article,and Carboplatin in the Albumin microsphere is determined by the chelating reaction-spectrophotometry at 392nm. There is a linear range from 10 to 50μg/m1,recoveries of Carboplatin from Albumin microsphere are more than 99.5%,RSD is less than 2%.The method is simple, sensitive and specific, suiting for the determination of both Carboplatin and Carboplatin in the preparation.
出处
《药物分析杂志》
CAS
CSCD
北大核心
1995年第1期41-43,共3页
Chinese Journal of Pharmaceutical Analysis
基金
"八五"全军医学科技攻关项目
关键词
卡铂
络合反应
白蛋白微球
分光光度法
Carboplatin
Chelating reaction
Albumin microsphere
Chelating reactionspectrophotometry
