摘要
目的：比较萘丁美酮与奈普生治疗类风湿关节炎（ＲＡ）疗效。方法：萘丁美酮组４４例，服１．０ｇ，ｑｎ，４ｗｋ，萘普生组３２例，服０．２５ｇ，ｂｉｄ，４ｗｋ，用双盲对照法。前组１２例、后组１０例服药延长至０．５ａ。结果：４ｗｋ总有效率前组为６６％，后组４７％，０．５ａ总有效率前组９２％，后组７０％，但均无统计学差异（Ｐ＞０．０５）。结论：２药对ＲＡ的疗效相似，但不良反应胃烧灼感与水肿，萘丁美酮少于萘普生。
AIM: To campare the therapeutic effects of nabumetone and naproxen in treating rheumatoid arthritis(RA). METHODS: Nabumetone group of 44 patients received 1.0g, qn, for 4 wk,naproxen group of 32 patients received 0.25g, bid, for 4 wk,in double-blind method. The therapeutic courses of 12 patients of the former group and 10 patients of the latter group were prolonged to 0.5a, RESULTS: Total response rate of the former group was 66%, that of the latter group was 47% at 4 wk. At 0. 5a total response rates were 92% and 70%, respectively, but with no significant difference(P>0.05). CONCLUSION: The therapeutic effects of both drugs in treating RA were similar, but the adverse reactions of heart burn and edema after nabumetone were less than those after naproxen.
出处
《新药与临床》
CSCD
北大核心
1995年第5期258-260,共3页
