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赖诺普利与依那普利对高血压的疗效比较 被引量:10

Lisinopril vs enalapril in treatment of essential hypertension
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摘要 92例原发性Ⅰ和Ⅱ期高血压病人采用随机、单盲方法,分2组治疗。一组用赖诺普利,po,20-80mg/d,另一组用依那普利,po,10-40mg/d,疗程均为4wk。降压总有效率和降压幅度:赖诺普利是89%和2.9/2.0kPa,依那普利是97%和3.1/2.1kPa,2药降压均显著(P<0.01),降压疗效相仿(P>0.05)。不良反应发生率是29%和34%,其中最多是干咳。结果提示赖诺普利治疗轻、中度高血压有效、安全。 The effect of lisinopril(20-80 mg/d)was compared with that of enalapril (10-40 mg/d) in a randomized,single-blind,paralled design in 92 patients with essential hypertension. Results showed that total effective rate with treated lisinopril and enalapril were 89% and 97%,respectively.No significant difference was observed between the 2drugs(P>0.05).The main adverse reaction was dry cough. There was no abnormal laboratory finding during treatment.The effective dosage of lisinopril was 10-40mg/d.It is concluded that lisinopril is an effective, safe and well tolerated antihypertensive agent for patients with mild to moderate hypertension.
出处 《新药与临床》 CSCD 北大核心 1995年第3期136-139,共4页
关键词 赖诺普利 依那普利 高血压 药理 lisinopril enalapril hypertension
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  • 1Dr. P. F. Semple,A. M. M. Cumming,P. A. Meredith,J. J. Morton. Onset of action of captopril, enalapril, enalaprilic acid and lisinopril in normal man[J] 1987,Cardiovascular Drugs and Therapy(1):45~50 被引量:1
  • 2B. A. M. Schaik,G. G. Geyskes,P. Boer. Lisinopril in hypertensive patients with and without renal failure[J] 1987,European Journal of Clinical Pharmacology(1):11~16 被引量:1

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