摘要
目的 探讨复方中药肝胆宁对豚鼠胆固醇结石(CS)形成的影响。 方法 以高胆固醇剥夺维生素C的致石饲料诱发豚鼠CS作动物模型。以肝胆宁(n=15)作防石药物,鹅去氧胆酸(n=15)作对照,进行了抑制CS形成的实验研究。 结果 肝胆宁能降低胆石发生率(防石组20％比致石组93.3％,n=15,P<0.005),并能降低胆汁CS的成石力(BA/CHO,防石组6.8±2.3比致石组2.1±1.8,LC/CHO,防石组6.8±5.2比致石组1.8±1.7,P<0.01)。此外,肝胆宁尚能降低豚鼠脂肪肝的发生率(防石组20％比致石组100％,n=15,P<0.005),其总体效用优于对照药物。 结论 肝胆宁通过对肝脏功能的调节,阻止其产生病理性致石胆汁而达到抑制CS形成。
AIM To investigate the effect of Chinese medicine, gandanning on the development of cholesterol stone (CS) in guinea pigs. METHODS With a high cholesterol, vitamine C deficient lithogenous diet, CS in guinea pigs was induced as an animal model. Gandanning was used as gallstone- protecting drug and chenodeoxycholic acid as control. A gallstone- preventing experimental study was carried out. RESULTS Gandanning could decrease the incidence of gallstones in guinea pigs(for prevention group, the incidence of gallstone was 20% vs lithogenous group, 93.3%, n = 15, P<0.005) and the lithogenous abili-ty in bile(BA/CHO for prevention group, 6.8 ± 2.3 vs lithogenous group 2.1±1.8; LC/CHO, 6.8±5.2vs 1.8 ± 1.7, n = 15, both P<0.01). In addition, gandanning also could reduce the incidence of fatty liver in guinea pigs(for prevention group, 20%, vs lithogenous group 100%, n = 15, P< 0.005). Its general efficacy was superior to chenodeoxycholic acid.CONCLUSION The action of gandanning on inhibiting the development of CS in guinea pigs should be contributed to its resisting the produce of pathogenetic lithogenous bile by regulating liver function.
