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丝裂霉素C动脉灌注对血管形态改变的研究 被引量:1

A STUDY OF ARTERIAL DAMAGE INDUCED BY ANTI-CANCER DRUG MITOMYCIN C INFUSION
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摘要 本实验采用剂量0.5mg/2ml及1.0mg/2ml的抗癌药丝裂霉素C对家兔颈外动脉行一次性灌注,于灌注后1、3、7d分别进行光镜及透射电镜检查。实验结果表明:颈外动脉内灌注MMC可造成该动脉系统不同分段的不同程度的损伤。光镜下动脉的损伤以内膜破坏性改变为特征;亚微结构的改变呈现ECs脱落、内膜通透性增高及血栓形成。 Anti-cancer drug, Mitomycin C (MMC), single dose of 0. 5mg/2ml or 1. 0mg/2ml, was directly infused into the external carotid artery of the rabbit. Morphological alterations in the infused artery were examined by light and electron microscopy at different times in one week after infu-sion. A brokenness of intimal layer and the damage in different sites in infused-arteries were visualized. Electron microscopy showed a loss of endothelial cells, an increase in the permeability of the intimal layer and the appearance of thrombi.
出处 《西安医科大学学报》 CSCD 1995年第2期151-153,共3页 Journal of Xi'an Medical University(Chinese)
关键词 丝裂霉素C 动脉灌注 血管形态 药物疗法 肿瘤 mitomycin C arterial chemo-infusion endothelial cells
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  • 1陈铁镇,衡阳医学院学报,1987年,50页 被引量:1
  • 2陈铁镇,中华病理学杂志,1985年,14卷,4期,248页 被引量:1
  • 3王兆元,中华心血管病杂志,1985年,13卷,4期,290页 被引量:1

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