摘要
用邻甲苯胺对小鼠亚急性染毒，观察对免疫功能影响。研究发现：脾脏是邻甲苯胺作用的一重要靶器官。免疫系统受到抑制，表现为１９ｍｇ／ｋｇ以上染毒引起脾脏增大，且呈剂量－反应关系；３８ｍｇ／ｋｇ以上引起白细胞计数和淋巴细胞比例升高，中性细胞比例下降；７６ｍｇ／ｋｇ引起Ｔ淋巴细胞百分比、抗体生成细胞和吞噬细胞吞噬功能下降。
The study found that spleen is an important target organ and the function of immune system is depressed.The spleen weight is increased with the amount of exposure above 19mg/kg body weight,which shows a dose-reaction relationship,White blood cell counts and lymphocyte percentage are increased,whereas neutrophil leukocyte percentage is decreased with the amount of exposure above 38mg/kg body weight.Lyphocyte percentage and the number of antibody forming cell and the phagocytosis of macrophage are decreased with the amount of exposure at 76mg/kg body weight.
出处
《卫生研究》
CAS
CSCD
北大核心
1995年第2期72-74,共3页
Journal of Hygiene Research
关键词
邻甲苯胺
小鼠
免疫
毒性
O-toluidine
mouse
immune
toxicity
