摘要
使用离体主动脉环，研究一氧化氮（ＮＯ）在四氯化碳（ＣＣｌ４）致肝硬变大鼠血管对苯肾上腺素（ＰＥ）低反应中的作用。结果显示，肝硬变大鼠主动脉环对ＰＥ反应性较正常明显减低（最大收缩反应分别为２８０．０±５０．０ｍｇ和３３８．３±３５．４ｍｇ，Ｐ＜０．０５），主动脉环去内皮或使用ＮＯ合成酶抑制剂左旋硝基精氨酸（ＬＮＮＡ），可使肝硬变主动脉环的收缩反应与正常比较无明显差异（Ｐ＞０．０５）。提示肝硬变时血管内皮合成ＮＯ增加，参与了血管对ＰＥ低敏感性的发生。
The purpose of this study was to investigate the effect of NO on response to phenylephrine(PE)in rats with carbon tetrachloride-induced cirrhosis.A hyporesponsiveness to PE was observed in vitro in aortic rings.(R(wan) was 280.0±50.0 mg in cirrhosis rats and 338.3±35.4 mg in normal control,P<0.05).This hyporesponsiveness to PE could be reversed by endothelium denudation or NO synthesis inhibitor N￣G-nitro-L-arginine.The results suggest that reduced vascular reactivity to PE and NO mediated this abnormality in cirrhotic rats.
出处
《同济医科大学学报》
CSCD
北大核心
1995年第4期279-281,共3页
Acta Universitatis Medicinae Tongji
基金
湖北省科委资助
关键词
一氧化氮
肝硬变
主动脉
血管收缩
nitric oxide
liver cirrhosis
aorta,thoracic
phenylephrine
vasoconstriction
