摘要
对３２例脑梗塞患者及１８例脑出血患者外周血单个核细胞（ＰＢＭＣ）ＩＬ－６和ＴＮＦα分泌水平进行了测定。结果表明：脑梗塞及脑出血患者ＩＬ－６水平分别为６３６．１３±７３．６２ｕ／ｍｌ和５６１．１１±８６．７２ｕ／ｍｌ；ＴＮＦα水平分别为１０５．２２±１８．１４ｕ／ｍｌ和７１．９４±１０．６４ｕ／ｍｌ。２４例健康老年人及２０例健康献血员ＩＬ－６水平分别为２６９．４６±３７．４９ｕ／ｍｌ和１６．７６±３．１６ｕ／ｍｌ；ＴＮＦα水平分别为２２．２０±４．６２ｕ／ｍｌ和９．１２±２．１４ｕ／ｍｌ。各组之间Ｐ值均小于０．０１，有显著差异。提示ＩＬ－６及ＴＮＦα与脑梗塞及脑出血的发病有一定相关性；老年人ＩＬ－６及ＴＮＦα水平有所改变。
In this paper,determination of TNFαand IL-6 produced by peripheral blood mononuclear cells(PBMC)in 32 cases of Cerebral Infarction in the elderly, 18 cerebral haemorrhage, 24 normal aged and 20 normal blood donors has been made.It was shown that TNFαand IL-6 levels of the patient with Cerebral Infarction are obviously higher than the normal aged(P<0.01),and TNFα,IL-6 levels of the normal aged are much higher than the no rmal blood donors(P<0.01).The result reveals that TNFαand IL-6 play a critical role in the pathogenesis of Cerebral Infarction, and the levels of TNFαand IL-6 do have the relation to physiology of aging.
出处
《天津医科大学学报》
1995年第2期4-6,共3页
Journal of Tianjin Medical University
基金
天津市卫生局资助
