摘要
从虾蟹等动物外壳中提取的甲壳素(〔(1.4)-2-乙酰氨基-2-脱氧-β-D葡聚糖〕),经二乙酰化反应后,用分散沉淀法包囊国产大孔吸附树脂(比表面积>600m^2/g, 平均孔径8.5mμ)可作为人工肝辅助器的吸附剂。用经二乙酰化甲壳素包囊的树脂和未经包囊的树脂分别作血液灌流治疗犬急性戊巴比妥中毒。结果表明,树脂包囊后不仅保留了很高的药物清除率,而且血相容性有明显改善,用二乙酰化甲壳素包囊的树脂很有希望在临床中替代未包囊的树脂。
<ABSTRACT>
This paper reports the use of diacetylchitin coated domestic macro-
reticular resin (surface area 600m2/g, average porosity 8.5mu) as an
adsorbent in artificial liver support. Chitin was extracted from the shel-
ls of small Crustacea (crabs and shrimps ) and diacetylized prior to
tise as a coating material. Sixteen dogs acutely intoxicated with pento-
barbital were hemoperfused either with the coated resin (n = 8 ) or the
raw resin (n = 8 ). Results showed. that coating greatly improved hemoco-
mpatibility of the resin. After 125 minutes of perfusion, the percentage
decrease in platelets and leucocytes was from 65% and 60% respectively
to 16% and 12%. Clearance rates for the coated and raw resins at a flow
rate of 200 ml/min for 5 minutes were respectively 195±5ml/min and
195±6ml/min. At the end of perfusion, the respective
(Continued on page 81 )
(Continued from page 85)
yalues were 156±30 ml/min and 159±16 ml/min. Diacetylchitin seems to
be a promising coating material as it has good hemocompatibility without
ad yersely affecting adsorption efficacy.
出处
《中国生物医学工程学报》
EI
CAS
CSCD
北大核心
1989年第2期82-85,共4页
Chinese Journal of Biomedical Engineering
基金
中国科学院基金资助课题
关键词
甲壳素
吸附剂
戊巴比妥
中毒
Adsorbents
Biocompatibility
Biological Materials
Blood
Biomedical Engineering
Patient Treatment
Chitin
