摘要
体外试验证明，由日本血吸虫成虫分离的血红蛋白酶（Ｈｂａｓｅ）能降解人血红蛋白（Ｈｂ）。紫外分光光度计（２８０ｎｍ）和色谱扫描分析显示，０．１、１．０和１０．０ｍｍｏｌ／Ｌ浓度的环孢霉素Ａ（ＣｓＡ）对Ｈｂａｓｅ的活性均有不同程度的抑制作用，其抑制率分别为１０．１６％、２０．５５％和２７．２５％。本研究结果提示，ＣｓＡ的抗血吸虫作用可能与血吸虫的Ｈｂａｓｅ活性受到抑制有关。
It has been demonstrated in vitro that hemoglobinase (Hbase) from Schistosoma japonicum adult could degrade human hemoglobin. The analysis of UV-photometer (280 nm ) and chromoscanner showed that the activity of Hbase was inhibited by cyclosporin A (CsA ) in concentration of 0. 1, 1. 0 and 10. 0 mmol/L with inhibitive rates of 10. 16%, 20. 55% and 27. 25% respectively. The results suggested that the antischistosome effect of CsA may be involved inhibition of Hbase activity.
出处
《实用寄生虫病杂志》
CAS
1995年第4期148-149,共2页
Journal of Practical Parasitic Diseases
