摘要
应用外源性前列环素（ＰＧＩ＿２）治疗急性胰腺炎（ＡＰ）大鼠，并观察其对胰腺血流量和血小板聚集率的影响。ＡＰ大鼠模型采用胰管内注射牛磺胆酸钠溶液，胰腺血流量应用￣８６ＲｂＣｌ组织摄取法，血小板聚集率采用ＡＤＰ诱导聚集法。结果表明，ＰＧＩ＿２治疗组胰腺血流量显著增加、血小板聚集率降低、腹水量减少、胰腺病理损害显著减轻、大鼠死亡率下降。提示ＰＧＩ＿２通过影响胰腺血液循环而改善ＡＰ大鼠预后。
The therapeutic role and it’s possible mechanisms of exogenous prostacyclin(PGI2)on acute pancreatitis(AP)in rats were investigated.One hundred and fifty nine SDrats were allocated into 3 groups randomly: Sham operation, AP untreated, and APtreated by PGI2. AP model was made by injection of 5% sodium taurocholate intothe bile-pancreatic duct pancreatic blood flow was measured using 86RbCl tissue inta-king technique,and PAgR was determined by ADP-induced aggregation method,PGI2sodium solution was applied intraperitioneally in doses of 25μg/kg at 10 after indu-ction of the disease. Results: 5 of 15 rats treated with PGI2 were alive at 24 hours,none of 15 control rats survived at 24 hours(P<0.05), the mean survival times wereprolonged from 11.35±6.18 hours in control group to 19.45±8.67 hours in PGI2-treated group. Treatment of FGI2 in AP resulted in not only the increase of PBF andPTP, but also the decrease of PAgR. Ascites reduced and pancreatic tissue damagelimitcd were also noted. The results indicate that the prostacyclin has a therapeuticeffect on AP in rats, possibly by improving pancreatic blood circulation.
出处
《上海医学》
CAS
CSCD
北大核心
1995年第6期322-324,共3页
Shanghai Medical Journal
