摘要
本文应用放射免疫分析法检测了２５例风心病二尖瓣狭窄患者行二尖瓣球囊成形术（ＰＢＭＶ）术前、术后的血浆心钠素（ＡＮＦ）浓度及用心导管术与用超声心动图检测其血液动力学参数，并探讨其相关性。结果发现患者血浆ＡＮＦ浓度行ＰＢＭＶ术后比术前显著下降（Ｐ＜Ｏ．００１），且ＡＮＦ浓度降低率与左房平均压降低率及二尖瓣跨瓣压差降低率均呈正相关。提示左房压升高是风心病二尖瓣狭窄患者ＡＮＦ分泌的重要刺激因素。
he changes of
plasma atrial natriuretic factor( ANF)were detected by
radioim-munoassay and the parameters of hemodynamics were measured by
cardioangiography and ul-trosonography rcspectevely in 25 patients
with rheumatic mitral stenosis after the percuta- neous balloon
mitral valvuloplasty ( PBMV).The results showed that the plasma ANF.
level decreased from 353.2 ± 177.75ng/L to 209.4 ± 134.08ng/Lafter
PBMV(P<0.001)。There was a significant correlation between the left
atrial pressure and ANF before and after the dilation(r=0. 39, P< 0.
05) There was a significant correlation between the pressureacross
the mitral valve and ANF before and after the dilation(r=0. 37,P<0.
05) Itsuggested that the increased left atrial pressure was an
important factor for ANF release inthe patients。
关键词
二尖瓣成形术
球囊成形术
心钠素
血液动力学
mitral
stenosis
percutaneous balloon mitral valvuloplasty
cardionatrin
