摘要
观察了再生障碍性贫血（ＡＡ）１６５例的淋巴细胞比值，用ＡＰＡＡＰ法和ＥＬＩＳＡ法测定Ｔ１３８例的Ｔ细胞亚群、８９例ＨＩＪＡ－ＤＲ抗原的表达及１６例ＰＢＭＮＣ培养上清的ＴＮＦα水平，用抗Ｔ淋巴细胞单克隆抗体ＳＭＵ３和ＳＭＵ８治疗了ＡＡ患者６３例。结果表明，ＡＡ患者体内细胞免疫功能紊乱，表现为Ｔ细胞亚群比例失衡，ＨＬＡ－ＤＲ抗原表达增高，ＴＮＦα分泌增加；用ＳＭＵ３、ＳＮＵ８单抗治疗ＡＡ的总有效率为７９．３％，且具有疗效快、副作用小、重复应用仍安全有效等优点。
To access the effect of cell immune function on the pathogenesis of aplastic anemia (AA),the percentage of lymphocyte was investigated, T lymphocyte subsets and the expression rate of HLA-DR antigen as well as the tumor necrosis factor alpha(SNFα)level were also analyzed. Anti-T lymphocyte monoclonal antibodies ( McAb-T ) SMU3 and SMU8 were used to treat 63 patients with AA. The results showed that there were cell immune function disturbance in AA patients, including T lymphocyte subsets imbalance, higher HLA-DR antigen expression and increased TNFα production. McAb-T SMU3, SMU8 could be used to treat AA with an effective rate 79.3%, it had more rapid therapeutic effect and fewer side effect compared with that of other immune suppressive agents. Repeated use was safe and effective.
出处
《山东医科大学学报》
1995年第4期312-316,共5页
Acta Academiae Medicinae Shandong
关键词
再生障碍性贫血
单克隆抗体
肿瘤坏死因子
T细胞
Anemia
aplastic
T lymphocyte subsets
HLA-DR
Antibodies
monoclonal
McAb-T
TNFα
