摘要
研究了新生牛肝细胞生长因子（ｃＨＧＦ）对ＣＣｌ４引起的大鼠急性肝损伤的保护作用。结果表明，ｃＨＧＦ可降低ＣＣｌ４引起的急性肝衰竭大鼠的死亡率，抑制血清谷丙转氨酶（ＧＰＴ）和胆红素（Ｂｉｌ）的升高。从肝组织切片观察到ｃＨＧＦ可明显减轻ＣＣｌ＿４引起的肝细胞结构的损伤，证实ＨＧＦ是一种有效的保肝活性因子。
A hepatocyte growth factor (HGF) was extracted from new born cattle liver. The Wistar rats were intraperitoneally (i.p.) injected with carbon tetrachloride (in soybean oil) at a dose of 4ml/kg body weight to induce hepatic injuries and the protective effect of HGF on thus induced hepatic damage was investigated. The results were as follows: l.HGF could decrease the death rate from 80% to 20%. 2.Hepatic histological findings indicated that the degree of CCl4 -induced hepatic lesions could be lessened by HGF. 3.HGF could suppress the elevation of sGPT and sBil induced by carbon tetrachloride intoxication.The results suggest that HGF is a potential active factor for protecting liver .
出处
《山东医科大学学报》
1995年第3期206-209,共4页
Acta Academiae Medicinae Shandong
关键词
肝细胞生长因子
肝疾病
四氯化碳
牛
大鼠
Hepatocyte growth factor
Carbon tetrachloride
Liver diseases
Cattle
Rats
