摘要
应用免疫组织化学方法观察７２例结直肠癌、１１例腺瘤、３０例癌旁粘膜及１５例正常粘膜ｐ５３蛋白表达及其与肿瘤临床病理学特征和预后的关系。结果显示：结直肠癌ｐ５３蛋白阳性率为５０％，腺瘤的阳性率为１８．１８％（Ｐ＜０．０５），阳性细胞主要分布在腺瘤的增生区或不典型增生区；正常粘膜、癌旁粘膜ｐ５３蛋白均阴性。ｐ５３蛋白阳性的结直肠癌多呈浸润性生长方式，且以浸润至浆膜外者居多，患者生存率较ｐ５３蛋白阴性者低（Ｐ＜０．０５），５年生存率分别为３５．８２％及６２．４９％。未发现ｐ５３蛋白过度表达与结直肠癌的分化程度、肿瘤间质反应、淋巴结转移、淋巴结反应及Ｄｕｋｅｓ分期之间的关系。结果提示结直肠腺瘤ｐ５３蛋白过度表达可为腺瘤有无恶变倾向提供线索；结直肠活检标本出现ｐ５３蛋白阳性细胞提示肿瘤性生长可能；ｐ５３蛋白阳性可作为估计结直肠癌预后的参考指标之一。
The expression of p53 was studied immunohistochemically in a series 72 colorectal carcinomas and 11 colorectal adenomas. The results are as follows:50% of the carcinomas and 18.18% of the adenomas showed positive staining(P<0.05). p53 positive foci in the adenoma were found in proliferative areas and dysplastic areas. In all cases examined,p53protein staining was negative in normal colorectal epithelium and adjacent mucosa. The p53protein positive cancers went on invasive growth frequently and most of them penetrated serous membrane,The prognosis was worse in the cases of colorectal carcinomas with p53expression than in those without,the 5-year survial rates being 35. 82%and 62.49%,respectively(P<0.05).No correlation was found between p53 expression in colorectal cancers and the tumor histologic grade,stromal responses,lymph node metastases and Dukes stage.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
1995年第2期88-91,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
P53蛋白
免疫组化
病理学
预后
大肠肿瘤
colorectal neoplasms
p53 protein
immunohistochemistry
pathology
prognosis
