摘要
选择符合WHO诊断标准的急性心肌梗塞(AMI)21例,心绞痛(AP)19例,应用放射免疫法动态观察血浆神经肽Y(NPY)含量变化,并以21例正常人作对照.结果显示:对照组NPY水平为 75.1±30.4Pg/ml,AMI组发病第1天NPY含量达峰值,为136.7±66.5pg/ml,显著高于正常组(P<0.05).发病第3天开始下降,第1周末趋于正常,为77.4±48.4pg/ml,与正常组比较无显著差异.AP组于心绞痛发作期NPY含量为159.3±98.5pg/ml,亦显著高于对照组(P<0.05);经治疗2周症状缓解后复查血浆NPY含量下降至118.9±54.3pg/ml,前后比较有显著差异(P<0.05).冠心病伴高血压者血浆NPY含量为186.9±103.1Pg/ml,显著高于不伴高血压者(111.7±45.5pg/ml,P<0.01);既往有吸烟史的冠心病患者,血浆NPY含量为181.8±193.1pg/ml,显著高于无吸烟史者(122.0±65.6pg/ml,P<0.05).提示:NPY水平在冠心病发病初期显著升高,其升高可能由于心肌缺血急性期交感神经兴奋性提高、释放活性增强所致,而高血压及吸烟可能也产生对NPY释放的影响.NPY参与了冠心病的发病机理及病理生理过程.
The changes of plasma neuropeptide Y(NPY) level were observed by RLA methodin 21 patients with acute myocardial infarction (AMI) and 19 patients with angina pectoris (AP) according to the diagnosis index of WHO. The plasma NPY level was 75. 1±30. 4pg/ml in normal control group. Whereas,the plasma NPY level reached peck(136. 7±66. 5pg/ml) in patients during tke first day after AMI occuring. It was higher than those in the normal group(P<0. 05). It began to decrease from the third day.came to normal level in the end of first week(77. 4±48. 4pg/ml). The plasma NPY level was 159. 3±98. 5pg/ml in AP patients during angina attack. It was significantly higher than those in the normal group (P<0. 05). After two week's treatment, the plasma NPY level was decreased to 118. 9±54. 3pg/ml which was very significant. The plasma NPY level in coronary heart disease (CHD) patients with hypertension was 186. 9±103. 1pg/ml. It is much higher than patients without hypertension (111. 7±45. 5pg/ml,P<0. 01). The plasma NPY level was 181. 9±93. 1pg/ml in CHD patients with smoke history. It is significantly higher than those without smoke history(122. 0±6. 6pg/ml,P<0. 05). The results showed:the plasms NPY level was increased significantly during the acute ischemic attack period of CHD. The possible release mechanism of NPY are the enhancement of sympathetic nerve systern activation during acute my-ocardial ischemia period. Hypertension and smoke history may also have some effect on the release of NPY. The NPY also plays a role in pathophysiological and pathogenetic machanism of CHD.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1995年第2期73-75,共3页
Journal of Clinical Cardiology
基金
国家自然科学基金课题
