摘要
对１６例同种异体肾移植者进行了血糖和口服葡萄糖耐量试验（ＯＧＴＴ）检测。结果ＯＧＴＴ的５个时间点中有４个在手术前后有显著差异（３０、６０、１８０ｍｉｎ：Ｐ＜０．０５，１２０ｍｉｎ：Ｐ＜０．０１），糖耐量异常总率为６２．５％（１０／１６），达到移植后糖尿病（ＰＴＤＭ）诊断者３例（１８．８％）。此外，本文还报告了２例肾移植并发高渗性非酮性糖尿病昏迷患者。认为如何防治ＰＴＤＭ及其严重并发病已成为临床肾移植中急需解决的研究课题，建议肾移植病人尤其是高龄肥胖病人宜行常规血糖检查或ＯＧＴＴ动态观察，对糖耐量异常者应注意免疫抑制剂的应用，并严格控制饮食。
Abstract Immunosuppressive agents has been suggested to deleterious effects on glucose metabolism. In 16 adult renal transplant recipients, an oral glucose tolerance test (OGTT) was performed, and blood glucose level monitorred. 4 of 5 time points of OGTT were signiflcantly highter in postoperation (30min, 60min, 180min:P<0. 05, 120min: P<0. 01). The total alterred OGTT was 62.5% (10/16) and 3 cases (18. 8%) reached diagnostic criterion of posttransplant diabetes mellitus (PTDM). Otherwise, we added to report 2 patients of hyperosmolar non-ketopic coma complicated by kidney allograft, We propose to supervise with OGTT routinely before and after operation, especialy in older, heavier patient, and take it seriously.
出处
《临床泌尿外科杂志》
北大核心
1995年第2期67-70,共4页
Journal of Clinical Urology
