摘要
目的评价血清肿瘤标志物CEA、CA19-9及CA72-4对食管癌、胃癌及大肠癌的诊断价值。方法采用放射免疫量度分析法测定68例消化道癌及54例消化道良性疾病患者血清CEA、CA19-9及CA72-4水平。结果血清CEA在胃癌阳性表达率为56·0%,大肠癌的阳性表达率为59·1%,在食管癌及消化道良性疾病的阳性率仅分别为4·8%和1·9%;CA19-9在胃癌及大肠癌阳性表达率分别为60·0%和27·3%,而在食管癌和消化道良性疾病的阳性率分别为9·5%和9·3%;CA72-4在胃癌及大肠癌阳性表达率分别为52·0%和59·1%,而在食管癌和消化道良性疾病的阳性率为4·8%和1·9%。结论血清CEA、CA19-9、CA72-4对鉴别胃肠道良恶性疾病有较大价值,联合检测比单项检测准确性更高。
Objective To evaluate the diagnostic value of three serum tumor markers for digestive tract cancer.Methods The IRMA were used to measure the serum levels of three tumor markers： eareinoembryomie antigen （ CEA）, Carbohydrate antigen 19-9 （ CA19-9 ） and carbohydrate antigen 72-4 （CA72-4） in 68 patients with digestive tract cancer and 54 patients with benign digestive tract disease. Results In patients with gastric cancer and colorectal cancer, the positive rates of serum CEA were 56. 0% and 59. 1% respectively, and in patients with esophageal cancer and with benign digestive disease ,the positive rates of serum CEA were 4. 8% and 1.9% respectively. In patients with gastric cancer and colorectal cancer,the positive rates of serum CA19-9 were 60. 0% and 27.3% respectively, and in patients with esophageal cancer and with benign digestive disease, the positive rates were 9.5 % and 9.3% respectively. In patients with gastric cancer and colorectal cancer, the positive rates of serum CA72-4 were 52. 0% and 59. 1% respectively, and in patients with esophageal cancer and with benign digestive disease, the positive rates of serum CA72-4 were 4. 8% and 1.9% respectively. Conclusion The detection of serum CEA CA19-9 and CA72-4 has great value in differentiating benign gastroenteric disease from malignant one, and the combined detection of above-mentioned indexes has better accuracy than that of the single index.
出处
《安徽医科大学学报》
CAS
北大核心
2005年第4期360-362,共3页
Acta Universitatis Medicinalis Anhui
