摘要
目的观察苦参素联合胸腺肽治疗慢性乙型肝炎(CHB)的疗效。方法采用苦参素注射液联合胸腺肽胶囊治疗CHB,并与干扰素联合胸腺肽疗效进行对比观察。HBsAg、HBeAg的检测采用ELISA法,HBVDNA斑点杂交和PCR定量检测。结果苦参素联合胸腺肽治疗CHB疗效达到60.0%(24/42),HBVDNA阴转率为42.2%(19/42),HBeAg阴转率为33.3%(14/42);与干扰素联合胸腺肽治疗CHB疗效相近,且不良反应少。结论苦参素联合胸腺肽治疗CHB有较好疗效,与干扰素联合胸腺肽疗效相近。
Objective： To investigate the clinic effect of oxyrnatrine combined with thymotide on chronic hepatitis B. Methods： 84 chronic viral hepatitis B patients were randomly allocated to oxymatrine with thymotide （treatment group） or interferon α2b with thymotide （control group）, and the changes of ALT, HBsAg, HBeAg and HBV DNA were observed and compared. Results： In the treatment group, the therapeutic effectiveness and the negative-converting rate of ALT, HBV DNA, and HBeAg were not significantly different from that of the control group. Conclusion： Oxymatrine with thymotide and interferon α2b with thymotide are equally effective to treat hepatitis B.
出处
《泸州医学院学报》
2005年第4期332-333,336,共3页
Journal of Luzhou Medical College
