摘要
以磷酸作催化剂,γ-丁内酯和苄胺反应合成了1-苄基-2-吡咯烷酮,研究了反应条件对反应的影响,确定的最佳工艺条件为:n(γ-丁内酯):n(苄胺):n(磷酸)=1.0:1.5:0.1,反应时间2h,反应温度为180～210℃;产物经减压蒸馏分离提纯,蒸馏后的残余物作催化剂循环使用,1-苄基-2-吡咯烷酮收率为91.6%,含量99.3%;产品用元素分析、红外光谱、核磁共振等进行了确证.
1-Benzyl-2-pyrrolidone was prepared by the reaction of γ-butyrolactone and benzylamine catalyzed by phosphoric acid. Factors influencing on the reaction were studied and the optimum reaction conditions were as follows： n（γ-butyrolactone） ： n（benzylamine） ： n （ phosphoric acid ） = 1.0 ： 1.5 ： 0. 1, reaction temperature was 180 - 210℃ and reaction time of 2h. The product was purified by distillation under reduced pressure, the residue remained after distillation could be used as catalyst in circulation. The yield of title compound was 91.6% and content of 1-benzyl-2-pyrrolidone was 99.3%.The final product was confirmed by elementary analysis, IR and ^1HNMR.
出处
《精细与专用化学品》
CAS
2005年第15期18-20,共3页
Fine and Specialty Chemicals
基金
山东省中青年科学家基金项目资助
