摘要
目的:利用家犬肾脏移植模型,探讨门静脉注射供体脾细胞诱导免疫耐受的机制。方法:应用供体家犬脾细胞行门静脉注射,一周后行肾脏移植,ELISA方法测定对照组、门静脉注射组、环孢素组肾移植后IL-2、IL-6水平。门静脉注射组、对照组进行移植肾病理检查。结果:在肾移植后门静脉注射组、环孢素组IL-2、IL-6水平低于对照组,有显著性差异。而门静脉注射组与环孢素组之间无差异。门静脉注射组移植肾病理检查病变轻于对照组。结论:供体家犬脾细胞行门静脉注射可诱导受体家犬产生免疫耐受。
Objective：To study the mechanism of immune tolerance induce by protal venous injection of donor spleen ceils on the dog model of renal transplantation. Methods： The donor spleen ceils were injected through the protal vein during operation, one week later, renal transplantation was performed. IL-2 and IL-6 were studied by method of ELISA. Results： Level of IL-2 and IL-6 in protal venous group and cyclosporin group was higher than that of comrol group. There were no difference between protal venous group and cyclosporin group. Conclusion： Immune tolerance could be produced by protal venous injection of donor spleen cells.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2005年第8期629-630,633,共3页
Chinese Journal of Immunology
关键词
肾脏移植
免疫耐受
细胞因子
Renal transplantation
Immune tolerance
Cytokine
