摘要
目的探讨CD105在结直肠癌中的表达及其作为肿瘤新生血管标记物的临床病理意义。方法应用免疫组织化学S-P法,检测65例结直肠癌手术切除标本中CD105单克隆抗体表达的微血管密度(MVD)及其与临床病理参素之间的关系。结果CD105在结直肠癌中表达的新生血管大多局限于肿瘤实质边缘,而在正常组织的血管无表达。CD105检测的MVD为35.80±8.88,MVD值与肿瘤浸润深度、淋巴结转移和Dukes分期密切相关,有非常显著性差异(P<0.01)。结论CD105表达的MVD值可以被认为是与肿瘤浸润、转移有关的1项重要指征。
Objective To determme the expression and climcopathological significance of CD105 as a marker of tumor-related angiogenesis in colorectal cancer. Methods S-P immunohistochemical staining with anti-CD105 monoclonal antibody was used to determine microvessal density（MVD） and its relationship with clinicopathological parameters in 65 cases of colorectal cancer. Results The CD105 was mostly expressed in vessels at the margin of tumor, but not in the vassels of normal tissues. The value of MVD withmarked CD105 was 35.80±8.88. The MVD was significantly associated with tumor invasive depth, lymphonode metastasis and Dukes stages（P〈0.001）. Conclusion MVD with marked CD105 can be considered as an important index which is associated with tumor invasion and metastasis.
出处
《实用癌症杂志》
2005年第3期270-272,共3页
The Practical Journal of Cancer
