摘要
目的 观察锌铜铁缺乏和强化补充后对初断乳大鼠血清、心肌线粒体超氧化物歧化酶活性的影响。方法 通过耗竭方式造成初断乳大鼠Zn、Cu、Fe单独和联合缺乏模型后强化补充相应营养素。造模成功及干预结束后,测定血清和线粒体总超氧化物歧化酶T- SOD活性。结果 Zn、Cu、Fe缺乏和补充对大鼠血清T- SOD活性无明显影响(P>0 .0 5 ) ,Zn、Cu、Fe缺乏和3种营养素联合缺乏可导致心肌线粒体T- SOD活性明显降低(P<0 .0 0 1) ,单独补充Zn、Cu、Fe和3种营养素联合补充可使大鼠心肌T- SOD活性显著增加(P<0 .0 0 1)。结论 Zn、Cu、Fe缺乏对初断乳大鼠心肌线粒体T- SOD活性有明显影响,提示重视婴幼儿期Zn、Cu、Fe联合微量元素营养补充具有重要意义。
Objective To evaluate the influence of the deficiency of Zn,Cu and Fe and intensive supplement on serum and myocardial superoxide dismutase （SOD） activity of weanling rats. Methods Zn,Cu and Fe alone or combined deficiency were induced by nutrient depletion, and subsequent replete with appropriate nutrient supplement. After intervention, serum and myocardial mitochondrial total SOD activity were detected. Results Decreased myocardial mitochondrial T-SOD activity caused by Zn,Cu and Fe alone or combined deficiency for three nutrients in rats were observed. After supplementing these nutrients, myocardial mitochondrial T-SOD activity increased significantly. Conclusion Zn,Cu and Fe deficiency in rats can reduce myocardial mitochondrial T-SOD activity,therefore,it is suggested that the deficiency of these nutrients may influence the growth and development of infant and young children.
出处
《公共卫生与预防医学》
2005年第2期1-3,共3页
Journal of Public Health and Preventive Medicine
