期刊文献+

丙戊酸钠对癫痫患儿血小板水平的影响 被引量:1

下载PDF
导出
摘要 目的探讨丙戊酸钠对癫痫患儿血小板数目的影响。方法对48例确诊的癫痫患儿行丙戊酸钠单药治疗,在服用前、服用6个月、1年时分别采其中指外周血,对其血小板数目进行测定,并与33例健康儿童对照。结果治疗组服用丙戊酸钠6个月、1年时的血小板值明显低于治疗前(P<0·01);且明显低于对照组同期水平(P<0·05,P<0·01),用药时间越长,降低越明显。结论丙戊酸钠可降低血小板数目,提示丙戊酸钠治疗期间血象检测的必要。
出处 《中国小儿血液》 2005年第3期136-137,共2页 China Child Blood
  • 相关文献

参考文献5

  • 1刘心洁,韩其政,孙若鹏.丙戊酸钠与止血异常[J].国外医学(儿科学分册),2002,29(1):51-52. 被引量:4
  • 2Engel J Jr. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia, 2001 ;42:796. 被引量:1
  • 3Pirmohamed M, Kitteringham NR, Park BK. The role of active metabolites in drug toxicity. Drug Saf, 1994 Aug; 11(2):114. 被引量:1
  • 4Verrotti A, Greco R, Matera V, etal. Platelet count and function in children receiving sodium valproate. Pediatr Neurol, 1999 Sep; 21(3):611. 被引量:1
  • 5May RB, Sunder TR. Henatologic manifestations of long- term valproate therapy. Epilepsia, 1993 Nov-Dec; 34(6):1098. 被引量:1

二级参考文献12

  • 1Meldrum BS. Update on the mechanism of action of antiepileptic drugs[J]. Epilepsia, 1996,37(Suppl 6):S4-11. 被引量:1
  • 2Loscher W. Valprote:a reappraisal of its pharmacodynamic properties and mechanisms of action on[J]. Prog Neurobiol, 1999,58(1):31 -59. 被引量:1
  • 3White HS. Comparative anticonvulsant and mehanistic profile of the established and newer antiepileptic drugs[J]. Epilepsia, 1999,40(Suppl 5):S2- 10. 被引量:1
  • 4Gidal B, Spencer N, Maly M, et al. Valproate- mediated disturbances of hemostasis: relationship to dose and plasma concentration[J]. Neuro logy, 1994,44(8):1418 - 1422. 被引量:1
  • 5Deglado MR, Riela AR, Mills J, et al. Thrombocytopenia secondary to high valproate levels in children with epilepsy[J]. J Child Neurol, 1994,9(3):311 -314. 被引量:1
  • 6Kis B, Szupera Z, Mezei Z, et al. Valproate treatment and platelet function: the role of arachidonate metabolites[J]. Epilepsia, 1999,40(3): 307 - 310. 被引量:1
  • 7Ward MM, Barbaro NM, Laxer KD, et al. Preoperative valproate administration does not increase blood 1oss during temporal lobectomy[J]. Epilepsia, 1996,37(1);98 - 101. 被引量:1
  • 8Verrotti A, Greco R, Matera V, et al. Platelet count and function inchildren receiving sodium valproate[J]. Pediatr Neurol, 1999,21 (3):611-614. 被引量:1
  • 9Tanindi S, Akin R, Koseoglu V, et al. The platelet aggregation in children with epilepsy receiving valproic acid[J]. Thromb Res, 1996,81 (4):471 - 476. 被引量:1
  • 10Tohen M, Castillo J, Baldessarini RJ, et al. Blood dyscrasias with carbamazepine and valproate: a pharmacoepidemiological study of 2228 patients at risk[J]. Am J Psychiatry, 1995,152(3):413- 148. 被引量:1

共引文献3

同被引文献7

引证文献1

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部